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7-Methyl Trimethoprim Analogues as Inhibitors of the Folate Metabolizing Enzymes.

✍ Scribed by Aleem Gangjee; Xin Lin; Sherry F. Queener

Publisher
John Wiley and Sons
Year
2003
Weight
166 KB
Volume
34
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

7-Methyl Trimethoprim Analogues as Inhib
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✍ Aleem Gangjee; Xin Lin; Sherry F. Queener πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 79 KB

## Abstract A series of 5‐(1‐phenylethyl)pyrimidines **2–10** (Table I) were designed and synthesized as potent and selective inhibitors of __Pneumocystis carinii (P. carinii), Toxoplasma gondii (T. gondii)__ and __Mycobacterium avium (M. avium)__ dihydrofolate reductases (DHFR). The structure of *

Synthesis of 2,6-diamino-5-[(2-substitut
Synthesis of 2,6-diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin-4(3h)-one as inhibitors of folate metabolizing enzymes
✍ Aleem Gangjee; Ying Wang; Sherry F. Queener; Roy L. Kisliuk πŸ“‚ Article πŸ“… 2006 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 562 KB

## Abstract magnified image A series of eleven novel 2,6‐diamino‐5‐[(2‐substituted phenylamino)ethyl]pyrimidin‐4(3__H__)‐one derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) and thymidylate synthase (TS). The synthesis of analogues **2a‐f, 3a** and **3e** was