✦ LIBER ✦

Synthesis of 2,6-Diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin-4(3H)-one as Inhibitors of Folate Metabolizing Enzymes.

✍ Scribed by Aleem Gangjee; Ying Wang; Sherry F. Queener; Roy L. Kisliuk

Publisher: John Wiley and Sons
Year: 2007
Weight: 24 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200716150

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

2,4-diamino-6-substituted-5- (4-carbetho

2,4-diamino-6-substituted-5- (4-carbethoxyphenylazo) pyrimidines as irreversible inhibitors of folic acid reductase

✍ J. Hampshire; P. Hebborn; A. M. Triggle; D. J. Triggle 📂 Article 📅 1966 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

Design, Synthesis and Biological Evaluat

Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

Synthesis of 5-[2-(Phenoxy)ethyl] Deriva

Synthesis of 5-[2-(Phenoxy)ethyl] Derivatives of 6-Methyluracil, 6-Methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, and 2-Imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one.

✍ M. S. Novikov; A. A. Ozerov; O. G. Sim 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 18 KB 👁 1 views

Synthesis and Structure of 2-Substituted

Synthesis and Structure of 2-Substituted of 2-Substituted Thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives.

✍ Jian-Chao Liu; Hong-Wu He; Ming-Wu Ding 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

Synthesis and Structure of 2-Substituted

Synthesis and Structure of 2-Substituted Thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

✍ Jian-Chao Liu; Hong-Wu He; Ming-Wu Ding 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 German ⚖ 96 KB 👁 1 views

## Abstract A series of new 2‐substituted 3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno[3′,2′: 5,6]pyrido[4,3‐__d__]pyrimidin‐4(3__H__)‐ones **8** were synthesized __via__ an aza‐__Wittig__ reaction. Phosphoranylideneamino derivatives **6a** or **6b** reacted with 4‐chlorophenyl isocyanate to give carbo

Design, synthesis and biological evaluat

Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan