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Synthesis and Structure of 2-Substituted Thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

✍ Scribed by Jian-Chao Liu; Hong-Wu He; Ming-Wu Ding

Publisher: John Wiley and Sons
Year: 2007
Tongue: German
Weight: 96 KB
Volume: 90
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200790103

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✦ Synopsis

Abstract

A series of new 2‐substituted 3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno[3′,2′: 5,6]pyrido[4,3‐d]pyrimidin‐4(3__H__)‐ones 8 were synthesized via an aza‐Wittig reaction. Phosphoranylideneamino derivatives 6a or 6b reacted with 4‐chlorophenyl isocyanate to give carbodiimide derivatives 7a or 7b, respectively, which were further treated with amines or phenols to give compounds 8 in the presence of a catalytic amount of EtONa or K~2~CO~3~. The structure of 2‐(4‐chlorophenoxy)‐3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno[3′,2′: 5,6]pyrido[4,3‐d]pyrimidin‐4(3__H__)‐one (8j) was comfirmed by X‐ray analysis.

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