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7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands

✍ Scribed by Samuel D. Banister; Louis M. Rendina; Michael Kassiou

Book ID
118426620
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
396 KB
Volume
22
Category
Article
ISSN
0960-894X

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The radiochemical synthesis of (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl)-7azabicyclo[2.2. llheptane ([W'lI\_) was accomplished by Kryptofixa 222 assisted nucleophilic no-carrier-added [18F]fluorination of (+/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (h). The average radiochemical yield of