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660 Discovery of a novel series of indoleamine 2,3-dioxygenase 2 (IDO2) selective inhibitors for probing IDO2 function in cancer

✍ Scribed by X. Liu; G. Yang; Q. Wang; L. Leffet; K. Katiyar; P. Waeltz; T. Burns; A. Combs; R. Newton; P. Scherle

Book ID: 119603343
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 46 KB
Volume: 8
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)72367-3

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the reduction of 17AAG by NQO1 is relatively stable to autooxidation and formation of the 17AAG hydroquinone may allow for increased levels of 17AAG intracellular drug accumulation via a slow autooxidation process. Another implication of the data is that the 17AAG hydroquinone may represent an alter