101 Combinatorial cancer therapy using a pharmacological inhibitor of indoleamine 2,3-dioxygenase (IDO), a target of the cancer suppression gene Bin1

✍ Scribed by A.J. Muller; J.B. DuHadaway; E. Sutanto-Ward; P.S. Donover; G.C. Prendergast

• Book ID: 118621286
• Publisher: Elsevier Science
• Year: 2004
• Tongue: English
• Weight: 145 KB
• Volume: 2
• Category: Article
• ISSN: 1359-6349
• DOI: 10.1016/s1359-6349(04)80109-5

✦ Synopsis

the reduction of 17AAG by NQO1 is relatively stable to autooxidation and formation of the 17AAG hydroquinone may allow for increased levels of 17AAG intracellular drug accumulation via a slow autooxidation process. Another implication of the data is that the 17AAG hydroquinone may represent an alternative conformation for binding to HSP90 (supported by CA51210).