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101 Combinatorial cancer therapy using a pharmacological inhibitor of indoleamine 2,3-dioxygenase (IDO), a target of the cancer suppression gene Bin1

โœ Scribed by A.J. Muller; J.B. DuHadaway; E. Sutanto-Ward; P.S. Donover; G.C. Prendergast


Book ID
118621285
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
145 KB
Volume
2
Category
Article
ISSN
1359-6349

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101 Combinatorial cancer therapy using a
โœ A.J. Muller; J.B. DuHadaway; E. Sutanto-Ward; P.S. Donover; G.C. Prendergast ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 145 KB

the reduction of 17AAG by NQO1 is relatively stable to autooxidation and formation of the 17AAG hydroquinone may allow for increased levels of 17AAG intracellular drug accumulation via a slow autooxidation process. Another implication of the data is that the 17AAG hydroquinone may represent an alter