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607 Hypoxia accelerates apoptotic type of cell death in cultured neurons

✍ Scribed by Ozawa Kentaro; Tamatani Michio; Ogawa Satoshi; Tohyama Masaya

Book ID: 119523129
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 101 KB
Volume: 28
Category: Article
ISSN: 0168-0102
DOI: 10.1016/s0168-0102(97)90219-4

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When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300