6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
✍ Scribed by Jiaqiang Cai; Mark Baugh; Darcey Black; Clive Long; D. Jonathan Bennett; Maureen Dempster; Xavier Fradera; Jonathan Gillespie; Fiona Andrews; Sylviane Boucharens; John Bruin; Kenneth S. Cameron; Iain Cumming; William Hamilton; Philip S. Jones; Allard Kaptein; Emma Kinghorn; Maurice Maidment; Iain Martin; Ann Mitchell; Zoran Rankovic; John Robinson; Paul Scullion; Joost C.M. Uitdehaag; Paul Vink; Paul Westwood; Mario van Zeeland; Leon van Berkom; Martijn Bastiani; Tommi Meulemans
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 783 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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📜 SIMILAR VOLUMES
The title compound, C 20 H 15 FN 4 O, was synthesized by the reaction of 5-amino-3-methyl-1-phenylpyrazole with ethyl 2cyano-3-(4-fluorophenyl)-1-acylate in glycol under microwave irradiation. The tetrahydropyridine ring adopts a distorted envelope conformation. The pyrazole ring forms a dihedral an
In the title molecule, C 20 H 22 N 2 O, the pyridine heterocycle has an envelope conformation. The crystal packing is stabilized by intermolecular N-HÁ Á ÁO hydrogen bonds, which link the molecules into chains along the [110] direction.
Dezaguanine mesylate (CI-908 mesylate, 3deazaguanine mesylate, 6amino-1,5-dihydro-4H-imidazo[4,5~\_]pyridin-4-one methanesulfonate, 71, a new a n t itumor agent, w a s l a b e l e d in t h e 2 -p o s i t i o n by use of a new s y n t h e s i s t o 3deazaguanine. imidazole-S-carboxylate (10) was conv