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6-hydroxydopamine lesions in anuran amphibians: A new model system for Parkinson's disease?

✍ Scribed by Endepols, Heike ;Schul, Johannes ;Gerhardt, H. Carl ;Walkowiak, Wolfgang


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
373 KB
Volume
60
Category
Article
ISSN
0022-3034

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✍ Igor Branchi; Ivana D'Andrea; Monica Armida; Tommaso Cassano; Antonella Pèzzola; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB 👁 1 views

## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio