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6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase

โœ Scribed by Frye, Stephen V.; Haffner, Curt D.; Maloney, Patrick R.; Mook, Robert A.; Dorsey, G. F.; Hiner, Roger N.; Batchelor, Kenneth W.; Bramson, H. Neal; Stuart, J. Darren


Book ID
120488406
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
371 KB
Volume
36
Category
Article
ISSN
0022-2623

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Steroidal 3-carboxy-20-ketones have been prepared within two structural series, the androsta-3,5-dienes and the estra-1,3,5-trienes, as potential inhibitors of types 1 and 2 steroid 5 alpha-reductase, the enzyme activity responsible for the final step in biosynthesis of dihydrotestosterone. These co