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5α-reductase inhibitors exhibit distinct effects on human keratinocytes and sebocytes in vitro

✍ Scribed by Seiffert, Kristina; Fritsch, Martin; Zouboulis, Christos C.

Book ID
119562247
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
183 KB
Volume
16
Category
Article
ISSN
0923-1811

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✍ Nakayama, Osamu; Hirosumi, Jiro; Chida, Noboru; Takahashi, Satoru; Sawada, Kozo; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 524 KB

## BACKGROUND. Steroid 5␣-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5␣-reductase. METHODS. Two isozymes of rat and human 5␣-reductases were expressed in 293 cells. In vivo effects o