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FK143, a novel nonsteroidal inhibitor of steroid 5α-reductase: (1) In vitro effects on human and animal prostatic enzymes

✍ Scribed by Hirosumi, J.; Nakayama, O.; Fagan, T.; Sawada, K.; Chida, N.; Inami, M.; Takahashi, S.; Kojo, H.; Notsu, Y.; Okuhara, M.

Book ID
123444375
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
664 KB
Volume
52
Category
Article
ISSN
0960-0760

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FRM146687, a novel steroid 5α-reductase
FRM146687, a novel steroid 5α-reductase inhibitor: In vitro and in vivo effects on prostates
✍ Nakayama, Osamu; Hirosumi, Jiro; Chida, Noboru; Takahashi, Satoru; Sawada, Kozo; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 524 KB

## BACKGROUND. Steroid 5␣-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5␣-reductase. METHODS. Two isozymes of rat and human 5␣-reductases were expressed in 293 cells. In vivo effects o