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Benzo[ c ]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

✍ Scribed by Guarna, Antonio; Machetti, Fabrizio; Occhiato, Ernesto G.; Scarpi, Dina; Comerci, Alessandra; Danza, Giovanna; Mancina, Rosa; Serio, Mario; Hardy, Kimber


Book ID
120155586
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
223 KB
Volume
43
Category
Article
ISSN
0022-2623

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Synthesis of 8-chloro-benzo[c]quinolizin
✍ Antonio Guarna; Ernesto G. Occhiato; Dina Scarpi; Chiara Zorn; Giovanna Danza; A 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 175 KB

AbstractÐThe synthesis of a series of dierently substituted 8-chloro-benzo[c]quinolizin-3-ones, as potent and selective human steroid 5a-reductase type 1 inhibitors, has been accomplished by a four-step procedure based on the TiCl 4 -promoted tandem Mannich±Michael cyclization of 2-silyloxy-1,3-buta