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Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

✍ Scribed by Antonio Guarna; Ernesto G. Occhiato; Fabrizio Machetti; Andrea Trabocchi; Dina Scarpi; Giovanna Danza; Rosa Mancina; Alessandra Comerci; Mario Serio


Book ID
108479051
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
254 KB
Volume
9
Category
Article
ISSN
0968-0896

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Synthesis of 8-chloro-benzo[c]quinolizin
✍ Antonio Guarna; Ernesto G. Occhiato; Dina Scarpi; Chiara Zorn; Giovanna Danza; A 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 175 KB

AbstractÐThe synthesis of a series of dierently substituted 8-chloro-benzo[c]quinolizin-3-ones, as potent and selective human steroid 5a-reductase type 1 inhibitors, has been accomplished by a four-step procedure based on the TiCl 4 -promoted tandem Mannich±Michael cyclization of 2-silyloxy-1,3-buta