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5,6,7-Trisubstituted 4-Aminopyrido[2,3- d ]pyrimidines as Novel Inhibitors of Adenosine Kinase

✍ Scribed by Perner, Richard J.; Gu, Yu-Gui; Lee, Chih-Hung; Bayburt, Erol K.; McKie, Jeffery; Alexander, Karen M.; Kohlhaas, Kathy L.; Wismer, Carol T.; Mikusa, Joe; Jarvis, Michael F.; Kowaluk, Elizabeth A.; Bhagwat, Shripad S.


Book ID
126275199
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
151 KB
Volume
46
Category
Article
ISSN
0022-2623

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new