5,6-Dihydro-1H, 4H-pyrazolo[4,3-f]pyrrolo[1,2-a][1,4]diazepines. Synthesis and pharmacological evaluation
✍ Scribed by S Vega; MS Gil; V Darias; CC Sánchez Mateo; MA Expósito; MJ Oset-Gasque; M Parramón; MP González
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 672 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The synthetic pathway leading to 5,6‐dihydro‐4__H__‐furo[3,2‐__f__]pyrrolo[1,2‐__a__][1,4]diazepines is described in four steps starting from α‐bromophenones __via__ 2‐amino‐3‐furonitriles.
-The first synthesis of a new type of 1,4-diazepine derivatives, compounds (VIII) and (X), from α-bromophenones (I) via intermediate 2-amino-3-furonitriles is described. -(FENG, XIAO; LANCELOT,
A facile approach to pyrazolo [4,3-e][1,4] diazepin-5,8-diones andpyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepin-5,10-diones is reported. Strategy involved the utility of α-amino acid as a three-atom segment in the construction of diazepine skeleton on the preformed pyrazole ring.
## Abstract Fused tricyclic 7‐phenyl‐5__H__‐thizolo[5,4‐__e__]pyrrolo[1,2‐__a__][1,4]diazepin‐10(9__H__)one (**10**) was prepared by thermolysis of 2‐phenyl‐4‐(1‐pyrrolylmethyl)thiazole‐5‐carbonyl azide (**9**) in acetic acid. In addition, starting from **10**, 7‐phenyl‐5__H__‐thiazolo [5,4‐__e__][