4H-Pyrrolo[1,2-a]thieno[3,2-f] and 4H-pyrrolo[1,2-a]thieno-[2,3-f][1,4]diazepines: Synthesis and Pharmacological Evaluation
✍ Scribed by Salvador Vega; M. Soledad Gil; Victoriano Darias; Candelaria C. Sánchez Mateo; Maria A. Expósito; Maria L. Tello; Luz M. Albertos
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 680 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0365-6233
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## Abstract The study of the chemical reactivity of methyloxopyrrolothienodiazepinones led to new derivatives such as oximes, methyloximes, hydrazones and alcohols and also, according to an intramolecular cyclization, to new oxazino[4,3‐__c__]pyrrolo[1,2‐__a__]thieno[3,2‐__f__][1,4]diazepines.
## Abstract The synthetic pathway leading to 5,6‐dihydro‐4__H__‐furo[3,2‐__f__]pyrrolo[1,2‐__a__][1,4]diazepines is described in four steps starting from α‐bromophenones __via__ 2‐amino‐3‐furonitriles.