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551 Irofulven (IROF) enhances the antiproliferative effects of oxaliplatin (oxa) in human colon and breast cancer cells

✍ Scribed by M. Serova; F. Calvo; E. Cvitkovic; F. Koeppel; V. Poindessous; A.K. Larsen; E.S. Van Laar; S.J. Waters; E. Raymond


Book ID
118621733
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
130 KB
Volume
2
Category
Article
ISSN
1359-6349

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## Abstract Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic mucosa. 5‐fluorouracil (5‐FU) or 5‐FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but wit