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A specific vascular endothelial growth factor receptor tyrosine kinase inhibitor enhances the antiproliferative effect of trastuzumab in human epidermal growth factor receptor 2 overexpressing breast cancer cell lines

✍ Scribed by Elizabeth M.H. Kim; Catherine Lobocki; Linda Dubay; Vijay K. Mittal


Book ID
116216462
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
680 KB
Volume
197
Category
Article
ISSN
0002-9610

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## Abstract Our results revealed that the blockade of epidermal growth factor receptor (EGFR) tyrosine kinase and protein kinase A (PKA) signaling pathways by specific inhibitors (PD153035 and Rp‐cAMPs) leads to a synergistic inhibition of EGF‐ and serum‐stimulated growth of human prostatic cancer