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53BP1 facilitates long-range DNA end-joining during V(D)J recombination

✍ Scribed by Difilippantonio, Simone; Gapud, Eric; Wong, Nancy; Huang, Ching-Yu; Mahowald, Grace; Chen, Hua Tang; Kruhlak, Michael J.; Callen, Elsa; Livak, Ferenc; Nussenzweig, Michel C.

Book ID
109897842
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
933 KB
Volume
456
Category
Article
ISSN
0028-0836

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d