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Hybrid joint formation in human V(D)J recombination requires nonhomologous DNA end joining

✍ Scribed by Sathees C. Raghavan; Jiangen Tong; Michael R. Lieber

Book ID
116410501
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
253 KB
Volume
5
Category
Article
ISSN
1568-7864

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d