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The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

✍ Scribed by Michael R Lieber; Yunmei Ma; Ulrich Pannicke; Klaus Schwarz


Book ID
116410259
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
358 KB
Volume
3
Category
Article
ISSN
1568-7864

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d