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531 Radiosensitivity enhancement by a histone deacetylase inhibitor (HDACI), trichostatin A in human glioblastoma cell lines

✍ Scribed by I.H. Kim; J.H. Kim; J.H. Shin

Book ID: 118620705
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 166 KB
Volume: 1
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(03)90563-5

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec