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5159066 Recombination activating gene (RAG-1)

Book ID
123490518
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
51 KB
Volume
11
Category
Article
ISSN
0734-9750

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Two closely-linked genes, Ragl and Rag2, are required for the recombination of V, D, and J gene segments to form the genes encoding V regions of Igs and T-cell receptors. In several mammalian species, chickens, and Xenopus laevis, the coding region of RAG1 lies within a single exon; its sequence is

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Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13
โœ Klaus Schwarz; Horst Hameister; Manfred Gessler; Karl-Heinz Grzeschik; Thomas E. ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Springer ๐ŸŒ English โš– 296 KB

The human recombination activating gene 1 (RAG1) has previously been mapped to chromosomes 14q and 11p. Here we confirm the chromosome 11 assignment by two independent approaches: autoradiographic and fluorescence in situ hybridization to metaphase spreads and analysis of human-hamster somatic cell