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5 Hypoxia-inducible factor 1 in cancer pathogenesis and therapy

✍ Scribed by G.L. Semenza


Book ID
119599775
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
44 KB
Volume
7
Category
Article
ISSN
1359-6349

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Hypoxia-inducible factor 1 and cancer pa
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## Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increa