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The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis

✍ Scribed by Christopher William Pugh; Peter John Ratcliffe


Book ID
114340590
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
309 KB
Volume
13
Category
Article
ISSN
1044-579X

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## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th