5-Aryl-4-hydroxy-3(2H)-isothiazolone 1,1-dioxide derivatives. Synthesis and carbon-13 NMR characterization
✍ Scribed by Rooney, C. S.; Cochran, D. W.; Ziegler, C.; Cragoe, E. J.; Williams, H. W. R.
- Book ID
- 127236675
- Publisher
- American Chemical Society
- Year
- 1984
- Tongue
- English
- Weight
- 809 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-3263
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Carbon-13 chemical shifts of eight 3H-1,4-benzodiazepine-2,5( lH, 4H)-diones are reported. The carbonyl chemical shifts have diagnostic value for distinguishing these diones from the isomeric 1,3-benzodiazepine-2,5-dione structures.
## Abstract Conjugate addition of ethyl acetoacetate to 2,2′‐sulfonylbis(1,3‐diarylprop‐2‐en‐1‐ones) afforded a diastereom‐eric mixture (in a ratio of ∼65:35) of 4‐acetyl‐2,6‐diaroyl‐3,5‐diaryl‐4‐ethoxycarbonylthiane‐1,1‐dioxides differing in configuration at C‐4. The stereochemistry of the diaster