𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Diastereoselective synthesis and 1H and 13C NMR study of 4-acetyl-2,6-diaroyl-3,5-diaryl-4-ethoxycarbonylthiane-1,1-dioxides

✍ Scribed by S. Renuga; S. Selvaraj; S. Perumal; A. Lycka; M. Gnanadeebam

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
98 KB
Volume
39
Category
Article
ISSN
0749-1581

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Conjugate addition of ethyl acetoacetate to 2,2′‐sulfonylbis(1,3‐diarylprop‐2‐en‐1‐ones) afforded a diastereom‐eric mixture (in a ratio of ∼65:35) of 4‐acetyl‐2,6‐diaroyl‐3,5‐diaryl‐4‐ethoxycarbonylthiane‐1,1‐dioxides differing in configuration at C‐4. The stereochemistry of the diastereomeric thianes was established by ^1^H, ^13^C and 2D NMR spectroscopic techniques such as H,H‐COSY, C,H‐COSY and NOESY. Copyright © 2001 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

1H and 13C NMR study of 6-aryl-3-cinchop
1H and 13C NMR study of 6-aryl-3-cinchopheny-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
✍ Xue-hui Liu; Hao Xu; Yi-ou Fang; Yu-xin Cui; Peng-fei Xu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB

## Abstract Ten new 1,2,4‐triazolo[3,4‐__b__]‐1,3,4‐thiadiazole derivatives were synthesized and their NMR spectra were analyzed by 1D and 2D NMR techniques (gCOSY, gHMBC, gHMQC). Copyright © 2001 John Wiley & Sons, Ltd.

Synthesis and characterization of 5-meth
Synthesis and characterization of 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-1,3,4,6-13C hydrochloride (Nefopam-13C hydrochloride)
✍ James E. Bunker; Richard A. Newmark 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 246 KB 👁 1 views

## Abstract Nefopam hydrochloride (I), an analgesic agent, was labelled with carbon‐13 at C‐1,3,4 and 6 positions for metabolic studies. The starting materials for the synthesis included commercially available phthalic acid‐carboxyl‐^13^C~1~ (II) and 2‐methylaminoethyl‐1,2‐^13^C~2~ alcohol. The ext