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[5-14C]-4-methyltriazolepyridines via facile preparation of methyl-[14C]-isothiocyanate

✍ Scribed by Peter Ström; Jonas Malmquist

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
113 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A fast and convenient microwave assisted one‐pot synthesis of methyl‐[^14^C]‐isothiocyanate 4 was shown. The continued one‐pot synthesis with 4 to a highly refined material like [5‐^14^C]‐dimethylsulfanyltriazolepyridines 8 and 13 without any intermediate purification, six steps in the same pot from [^14^C]KCN. Oxidation of the sulfur provided access to triazole‐ethers upon reaction with alcohols. The triazole‐ethers, 15, were obtained at fair to good yields and specific activities above 2 GBq/mmol. Copyright © 2008 John Wiley & Sons, Ltd.

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