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498 Selective potentiation of the hypoxic cytotoxicity of the bioreductive drug tirapazamine

โœ Scribed by B.G. Siim; R. Patel; F.B. Pruijn; M.P. Hay; W.R. Wilson


Book ID
118621680
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
108 KB
Volume
2
Category
Article
ISSN
1359-6349

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New cytotoxic mechanism of the bioreduct
โœ Peck-Sun Lin; Kwei-Chi Ho ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 834 KB

Tirapazamine (Tira, SR 4233), a Bioreductive agent, is highly toxic to cells under low oxygen conditions because it produces a toxic oxidizing radical intermediate. The mechanisms for its toxicity under aerobic conditions have not been fully established but involve reactive oxygen species production