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Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

✍ Scribed by Friery, O P; Gallagher, R; Murray, M M; Hughes, C M; Galligan, E S; McIntyre, I A; Patterson, L H; Hirst, D G; Langrish, V

Book ID
111724235
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
102 KB
Volume
82
Category
Article
ISSN
0007-0920

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## Abstract ## Background AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4. Most solid tumours are known to contain regions of hypoxia whereas levels of CYPs have been found to vary considerably. Enhancement of CYP levels may be obtained using gene‐directed enzy