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AQ4N and tirapazamine enhance antitumour effects of cyclophosphamide


Book ID
120870173
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2000
Weight
136 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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## Abstract ## Background AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4. Most solid tumours are known to contain regions of hypoxia whereas levels of CYPs have been found to vary considerably. Enhancement of CYP levels may be obtained using gene‐directed enzy

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Cyclophosphamide (CP) is a potent antitumour agent used against many forms of cancer and against certain other diseases. Chlorophyllin (CHL), which is obtained by hydrolysis of chlorophyll to remove phytyl alcohol, is an efficient antimutagenic agent and has been used as a dietary supplement or to d