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Potentiation of cisplatin activity by the bioreductive agent tirapazamine

✍ Scribed by Dietmar W Siemann; Cheri A Hinchman

Book ID
118262915
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
176 KB
Volume
47
Category
Article
ISSN
0167-8140

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✍ Peck-Sun Lin; Kwei-Chi Ho πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 834 KB

Tirapazamine (Tira, SR 4233), a Bioreductive agent, is highly toxic to cells under low oxygen conditions because it produces a toxic oxidizing radical intermediate. The mechanisms for its toxicity under aerobic conditions have not been fully established but involve reactive oxygen species production