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494 A phase I trial of SCH900776, a selective inhibitor of checkpoint kinase CHK-1, in combination with Gemcitabine in advanced solid tumors

✍ Scribed by A. Daud; C. Soon; G. Springett; D. Mendelson; P. Munster; J. Goldman; J. Strosberg; G. Kato; J. Horowitz; L. Rosen


Book ID
119603177
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
48 KB
Volume
8
Category
Article
ISSN
1359-6349

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi