484 Biological markers associated with sensitivity of tumour cells to the epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 and ionizing radiation
β Scribed by S. Burdak-Rothkamm; C.E. Ruebe; T.P. Nguyen; D. Ludwig; K. Feldmann; T. Wiegel; C. Ruebe
- Book ID
- 118620658
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 169 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1359-6349
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High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant