880 Prostate cancer cell proliferation is strongly reduced by combination treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (‘Iressa’) and the anti -androgen bicalutamide (‘casodex’)
✍ Scribed by M. Bologna; A. Angelucci; C. Festuccia; G.L. Gravina; P. Muzi; C. Vicentini
- Book ID
- 118621045
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 166 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1359-6349
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## Abstract The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is therefore a potential target for anticancer therapy. We evaluated the effects of ZD1839 (‘Iressa’), an orally a
High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant