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484 Apolipoprotein E allelic variation and receptor interaction in Alzheimer disease

✍ Scribed by O. Heinonen; S. Ylä-Herttuala; P. Riekkinen Sr; H. Soininen

Book ID: 118578061
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 127 KB
Volume: 17
Category: Article
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(96)80486-6

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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐