Apolipoprotein E Alleles and Brain Vascular Pathology in Alzheimer's Disease
β Scribed by R. N. KALARIA; D. L. COHEN; D.R.D. PREMKUMAR
- Book ID
- 119873372
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 245 KB
- Volume
- 777
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause earlyβonset AD. The apolipoprotein E (APOE) gene contributes primarily to lateβonset AD. The APOEβ
Recent studies have 'found an association between presence of apolipoprotein E (APOE) β¬4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the β¬4 allele with the relative