Apolipoprotein E-∈A allele and Alzheimer's disease
✍ Scribed by Naveed Anwar; Simon Lovestone; MichaelE Cheetham; Raymond Levy; JohnF Powell; Philippe Amouyel; Thierry Brousseau; Jean-Charles Fruchart; Jean Dallongeville; G Lucotte; F David; S Visvikis; B Leininger-Müller; G Siest; M.C Babron; R Couderc; Christian Czech; Ursula Mönning; PenttiJ Tienari; Tobias Hartmann; Colin Masters; Konrad Beyreuther; Hans Förstl; Yoav Ben-Shlomo; Glyn Lewis; PaulM McKeigue
- Book ID
- 119067043
- Publisher
- The Lancet
- Year
- 1993
- Tongue
- English
- Weight
- 493 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐
Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative