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4.6 Detection and Analysis of TP53 and ATM Deletions by Multiplex Ligation-Dependent Probe Amplification in CLL

✍ Scribed by Hazel M. Robinson; Jade Forester; Anne Gardiner; David G. Oscier; Anton E. Parker

Book ID: 119218919
Publisher: Elsevier
Year: 2011
Tongue: English
Weight: 99 KB
Volume: 11
Category: Article
ISSN: 2152-2650
DOI: 10.1016/j.clml.2011.09.126

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## Abstract __Background__: Multiplex ligation‐dependent probe amplification (MLPA) has been used to detect deletions and mutations of the α‐globin gene for diagnosis of α‐thalassemia. MLPA reaction products are usually separated and analyzed by high‐voltage capillary gel electrophoresis (CGE). The