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Detection of Deletions/Duplications in α-Globin Gene Cluster by Multiplex Ligation-Dependent Probe Amplification

✍ Scribed by Nezhat, Naghmeh; Akbari, Mohammad Taghi


Book ID
121259111
Publisher
Mary Ann Liebert
Year
2012
Tongue
English
Weight
466 KB
Volume
16
Category
Article
ISSN
1945-0265

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## Abstract __Background__: Multiplex ligation‐dependent probe amplification (MLPA) has been used to detect deletions and mutations of the α‐globin gene for diagnosis of α‐thalassemia. MLPA reaction products are usually separated and analyzed by high‐voltage capillary gel electrophoresis (CGE). The