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41 Genome-wide mutational signatures of aristolochic acid in urothelial cancer

✍ Scribed by Poon, S.L.; Pang, S-T.; McPherson, J.R.; Yu, W.; Huang, K.K.; Guan, P.; Weng, W-H.; Siew, E.Y.; Liu, Y.; Heng, H.L.; Chong, S.C.; Gan, A.; Tay, S.T.; Lim, W.K.; Cutcutache, I.; Huang, D.; Ler, L.D.; Nairismägi, M-L.; Lee, M.H.; Chang, Y-H.; Yu, K-J.; Chan-On, W.; Li, B-K.; Yuan, Y-F.; Qian, C-N.; Ng, K-F.; Wu, C-F.; Hsu, C-L.; Bunte, R.; Stratton, M.; Futreal, A.; Sung, W-K.; Chuang, C-K.; Ong, C.K.; Rozen, S.; Tan, P.; Teh, B.T.

Book ID: 123288770
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 115 KB
Volume: 13
Category: Article
ISSN: 1569-9056
DOI: 10.1016/S1569-9056(14)60043-9

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## Abstract The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds of __Aristolochia__ spp, which contain high levels of aristolochic acids (AA). Recently, tumour DNA samples from patients with BEN were found to