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Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

โœ Scribed by Alexandrov, Ludmil B; Stratton, Michael R


Book ID
121679818
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
400 KB
Volume
24
Category
Article
ISSN
0959-437X

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Recently, the genome sequences from several cancers have been published, along with the genome from a noncancer tissue from the same individual, allowing the identification of new somatic mutations in the cancer. We show that there is significant variation in the density of mutations at the 1-Mb sca