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1164 TP53 Mutational Signature of Aristolochic Acid in Carcinomas of the Upper Urinary Tract

✍ Scribed by Slade, N.; Moriya, M.; Brdar, B.; Jelakovic, B.; Medverec, Z.; Tomic, K.; Karanovic, S.; Fernandes, A.; Wu, L.; Grolmann, A.


Book ID
123311037
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
57 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Abstract The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds of __Aristolochia__ spp, which contain high levels of aristolochic acids (AA). Recently, tumour DNA samples from patients with BEN were found to