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TP53 mutations and HPV infections in tumours of the upper aerodigestive tract from Latin America

✍ Scribed by K. Szymañska; J.E. Levi; A.W. Daudt; V. Wünsch-Filho; J. Eluf-Neto; M.P. Curado; S. Koifman; A. Menezes; E. Matos; L. Fernandez; P. Boffetta; M. Tommassino; T. Gheit; P. Hainaut; P. Brennan

Book ID
119599097
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
85 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGG→AGT at codon 249, Arg→Ser) has been identified as a hotspot in HCCs from such areas,