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4-Substituted Piperidines. I. Derivatives of 4-t-Amino-4-piperidinecarboxamides

โœ Scribed by van de Westeringh, Cornelis; Van Daele, Paul; Hermans, Bert; Van der Fycken, Cyriel; Boey, Jozef; Janssen, Paul A. J.


Book ID
120562012
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
588 KB
Volume
7
Category
Article
ISSN
0022-2623

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Synthesis of N- Substituted 4-(4-Hydroxy
โœ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ฯ‰-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent