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Synthesis of N′-substituted 4-amino piperidines with a shielded nitrogen atom

✍ Scribed by E. S. Nikit-skaya; L. M. Alekseeva; Yu. N. Sheinker; L. N. Yakhontov


Book ID
112489267
Publisher
Springer US
Year
1971
Tongue
English
Weight
500 KB
Volume
7
Category
Article
ISSN
0009-3122

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Synthesis of N- Substituted 4-(4-Hydroxy
✍ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ω-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent