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4-Substituted Anilino Imidazo[1,2-a] and Triazolo[4,3-a]quinoxalines. Synthesis and Evaluation of in vitro Biological Activity.

✍ Scribed by Paola Corona; Gabriella Vitale; Mario Loriga; Giuseppe Paglietti; Paolo La Colla; Gabriella Collu; Giuseppina Sanna; Roberta Loddo

Publisher: John Wiley and Sons
Year: 2007
Weight: 24 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200704149

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## Abstract Some 1,2,4‐triazolo[4,3‐__a__]quinoxalines 1–10, and 1,2,4‐triazino[4,3‐__a__]quinoxalines 11–12 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The BZR affinity of 1–10 demonstrates that the presence of a proton