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Synthesis of 4-substituted imidazo[1,2-a]quinoxalines

✍ Scribed by Clemens Lamberth


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
24 KB
Volume
341
Category
Article
ISSN
1615-4150

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πŸ“œ SIMILAR VOLUMES


One-pot synthesis of imidazo[1,2-b]pyraz
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Hydrazonoyl bromides 1a-c react with 5-amino-3phenyl-1H-pyrazole, 5-amino-1H-1,2,4-triazole, 2aminopyridine, 2-aminopyrimidine, and 2-aminobenzimidazole to afford the corresponding imidazo[1,2-b]pyrazoles 10, imidazo[1,2-b]-1,2,4-triazoles 11, imidazo[1,2-a]pyridines 16, imidazo[1,2-a]pyrimidines 17

Regioselective Anionic [3+2] Cyclization
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and 3-aminopyrazole and 3-amino-1,2,4-triazole provide convenient access to biologically relevant 3H-imidazo[1,2-b]pyrazoles and a 5H-imidazo[2,1-c][1,2,4]triazole.

Tricyclic Heteroaromatic Systems. 1,2,4-
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## Abstract Some 1,2,4‐triazolo[4,3‐__a__]quinoxalines 1–10, and 1,2,4‐triazino[4,3‐__a__]quinoxalines 11–12 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The BZR affinity of 1–10 demonstrates that the presence of a proton

Reactions with hydroxamoyl halides: Synt
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Benzofuroylhydroxamoyl chloride (3) reacted with acrylonitrile, N-tolylmaleimide and active methylene compounds to afford the isoxazoline 4, the pyrrolidino13,4-d]isozazoline 5 and the isoxazole derivatives 6, 7, respectively. Nitrosoirnidazo[ 1,2-alpyridines 10 and the imidazo[ 1,2-alpyrimidine 12